It’s essential to highlight that these peptides are not intended for standalone use. Moreover, any effective weight-loss regimen MUST be coupled with proper nutrition and some form of exercise. It’s important to recognize that no medication will ever surpass the influence of unhealthy habits. That being said, these peptides serve as valuable “tools.”
They aid in fine-tuning insulin sensitivity, boosting mitochondrial function, reducing systemic inflammation, and managing hunger pangs. These tools aim to facilitate the adoption of choices aligned with your weight-loss goals—ensuring not only that you lose the weight, more importantly, that you keep it off!
They aid in fine-tuning insulin sensitivity, boosting mitochondrial function, reducing systemic inflammation, and managing hunger pangs. These tools aim to facilitate the adoption of choices aligned with your weight-loss goals—ensuring not only that you lose the weight, more importantly, that you keep it off!
Semaglutide
31 amino acids
7 day half-lif
This is the 1st generation of peptides called Glucagon-like peptides (GLP). It was first approved for the treatment of type 2 diabetes, and later for chronic weight management for obesity. GLPs mechanism of action reduce the release of glucose through the liver, increases insulin production via the pancreas, delaying stomach emptying, and stimulating neural pathways in the brain causing a sense of fullness. In short, it suppresses hunger by slowing metabolism. As a result, this causes a person to eat less, feel satiated for longer, and avoid food binging. Although approved for diabetes and obesity, Semaglutide CAN be used as a “bio-hack” for non-diabetic or obese individuals. Just one dose works around the clock for an entire week, which makes it really convenient to use. In the clinical trials, participants saw a 15%-22% decrease in body weight within 6-8 weeks. That’s an average of 33 pounds lost!
Here is a study about the benefits of Semaglutide by PubMed Central (PMC)
7 day half-lif
This is the 1st generation of peptides called Glucagon-like peptides (GLP). It was first approved for the treatment of type 2 diabetes, and later for chronic weight management for obesity. GLPs mechanism of action reduce the release of glucose through the liver, increases insulin production via the pancreas, delaying stomach emptying, and stimulating neural pathways in the brain causing a sense of fullness. In short, it suppresses hunger by slowing metabolism. As a result, this causes a person to eat less, feel satiated for longer, and avoid food binging. Although approved for diabetes and obesity, Semaglutide CAN be used as a “bio-hack” for non-diabetic or obese individuals. Just one dose works around the clock for an entire week, which makes it really convenient to use. In the clinical trials, participants saw a 15%-22% decrease in body weight within 6-8 weeks. That’s an average of 33 pounds lost!
Here is a study about the benefits of Semaglutide by PubMed Central (PMC)
Tirzepatide
39 amino acids
5 day half-life
This is the 2nd generation of GLPs for the treatment of type 2 diabetes. We call it a second generation because it is a dual combination peptide which modulates the activity of two important hormones in glucose regulation- GLP and GIP(Glucose-Dependent Insulinotropic Peptide). The GIP portion of Tirzepatide primarily targets the GIP receptor, enhancing its activity and promoting insulin secretion when blood sugar levels rise. By combining the actions of both GLP and GIP, tirzepatide helps regulate blood glucose levels more effectively than GLP alone.
Here is a study about the benefits of Tirzepatide by PubMed Central (PMC)
5 day half-life
This is the 2nd generation of GLPs for the treatment of type 2 diabetes. We call it a second generation because it is a dual combination peptide which modulates the activity of two important hormones in glucose regulation- GLP and GIP(Glucose-Dependent Insulinotropic Peptide). The GIP portion of Tirzepatide primarily targets the GIP receptor, enhancing its activity and promoting insulin secretion when blood sugar levels rise. By combining the actions of both GLP and GIP, tirzepatide helps regulate blood glucose levels more effectively than GLP alone.
Here is a study about the benefits of Tirzepatide by PubMed Central (PMC)
AOD-9604
15 amino acids
20-30 minute half-life
This is another FDA-approved peptide well-known as an anti-obesity drug proven to have a robust fat burning capacity, It activates degradation and fat burning (oxidation) by a method that doesn’t use the growth hormone receptor. It reduces abdominal fat stores by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the transformation of nonfat food materials into body fat). It has also demonstrated regenerative properties, cartilage repair and regenerative, especially when paired with peptide BPC-157.
Here is a study about the benefits of AOD by the The Journal of Clinical Endocrinology and Metabolism Journal
20-30 minute half-life
This is another FDA-approved peptide well-known as an anti-obesity drug proven to have a robust fat burning capacity, It activates degradation and fat burning (oxidation) by a method that doesn’t use the growth hormone receptor. It reduces abdominal fat stores by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the transformation of nonfat food materials into body fat). It has also demonstrated regenerative properties, cartilage repair and regenerative, especially when paired with peptide BPC-157.
Here is a study about the benefits of AOD by the The Journal of Clinical Endocrinology and Metabolism Journal
5-Amino-1MQ
5 amino acids
5-6 hour half-life
This is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT). As fat cells grow larger they begin to overproduce NNMT, which is responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. This enzyme increases the metabolism within the white fat cells and reduces the size of fat deposits, while also increasing longterm muscle contractile force by 70%.
Here is a study about the benefits of 5-Amino 1MQ by PubMed Central (PMC)
5-6 hour half-life
This is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT). As fat cells grow larger they begin to overproduce NNMT, which is responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. This enzyme increases the metabolism within the white fat cells and reduces the size of fat deposits, while also increasing longterm muscle contractile force by 70%.
Here is a study about the benefits of 5-Amino 1MQ by PubMed Central (PMC)
MOTS-C
16 Amino Acids
20-30 minute half-life
This a 16-amino acid poly-peptide encoded by mitochondrial DNA. Mitochondria are responsible for 95% of our bodies energy production. MOTS-C increases cellular respiration, reduces HA-1C, promotes metabolic homeostasis, and improves insulin resistance for massive fat loss and hyper-enhanced exercise performance.
Here is a study about the benefits of MOTS-C by the National Center for Biotechnology Information (NCBI)
20-30 minute half-life
This a 16-amino acid poly-peptide encoded by mitochondrial DNA. Mitochondria are responsible for 95% of our bodies energy production. MOTS-C increases cellular respiration, reduces HA-1C, promotes metabolic homeostasis, and improves insulin resistance for massive fat loss and hyper-enhanced exercise performance.
Here is a study about the benefits of MOTS-C by the National Center for Biotechnology Information (NCBI)
Tesofensine
8 day half-life
Although not a peptide this is the newest, game-changing form of a peptide–re-uptake inhibitors for weight loss! As a serotonin-noradrenaline-dopamine re-uptake inhibitor, Tesofensine works at the level of the brain by suppressing appetite, satiating reward centers, and increasing resting energy expenditure (your resting metabolic rate). It acts primarily as an appetite suppressant with significant effects on fat oxidation and reduction in fat tissue. Studies have shown a reduction in appetite sensation within 14 days, with those being treated reporting a greater satiety level and less desire to eat.
Here is a study about the benefits of Tesofensine by The American Diabetes Association
Although not a peptide this is the newest, game-changing form of a peptide–re-uptake inhibitors for weight loss! As a serotonin-noradrenaline-dopamine re-uptake inhibitor, Tesofensine works at the level of the brain by suppressing appetite, satiating reward centers, and increasing resting energy expenditure (your resting metabolic rate). It acts primarily as an appetite suppressant with significant effects on fat oxidation and reduction in fat tissue. Studies have shown a reduction in appetite sensation within 14 days, with those being treated reporting a greater satiety level and less desire to eat.
Here is a study about the benefits of Tesofensine by The American Diabetes Association
