Weight Loss
It’s essential to highlight that these peptides are not intended for standalone use. Moreover, any effective weight-loss regimen MUST be coupled with proper nutrition and some form of exercise. It’s important to recognize that no medication will ever surpass the influence of unhealthy habits. That being said, these peptides serve as valuable “tools.”
They aid in fine-tuning insulin sensitivity, boosting mitochondrial function, reducing systemic inflammation, and managing hunger pangs. These tools aim to facilitate the adoption of choices aligned with your weight-loss goals—ensuring not only that you lose the weight, more importantly, that you keep it off!
Semaglutide
31 amino acids & 7 day half-life
This is the 1st generation of peptides called Glucagon-like peptides (GLP), originally approved for type 2 diabetes and later for chronic weight management. GLP reduces glucose release from the liver, increases insulin production, delays stomach emptying, and stimulates brain pathways that create a sense of fullness—ultimately suppressing hunger and aiding weight loss. Semaglutide can also be used as a “bio-hack” for non-diabetic or non-obese individuals, with a single weekly dose proving highly convenient and clinical trials showing up to 22% body weight reduction in 6–8 weeks.
Tirzepatide
39 amino acids & 5 day half-life
This is the 2nd generation of GLPs for the treatment of type 2 diabetes. We call it a second generation because it is a dual combination peptide which modulates the activity of two important hormones in glucose regulation- GLP and GIP(Glucose-Dependent Insulinotropic Peptide). The GIP portion of Tirzepatide primarily targets the GIP receptor, enhancing its activity and promoting insulin secretion when blood sugar levels rise. By combining the actions of both GLP and GIP, tirzepatide helps regulate blood glucose levels more effectively than GLP alone.
AOD-9604
15 amino acids & 20-30 minute half-life
This is another FDA-approved peptide known as an anti-obesity drug proven to have robust fat burning capacity. It effectively reduces abdominal fat stores by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the transformation of nonfat food materials into body fat). It has also demonstrated regenerative properties, supporting cartilage repair and tissue regeneration, especially when paired with peptide BPC-157. This dual action makes it highly valuable for metabolic optimization, accelerated healing, and enhanced physical recovery.
SS-31 (Elamipretide)
4 amino acids & has a half life of roughly 1 hour (varies slightly by tissue)
It’s a 4-amino acid peptide that targets the mitochondria — the energy-producing engines inside your cells — and protects them from internal damage caused by oxidative stress. It binds to the inner mitochondrial membrane, stabilizes it, reduces electron leakage and harmful free radical production, allowing cells to generate cleaner, more efficient cellular energy. What it means for you: more energy, better focus, faster recovery, enhanced endurance, and slower aging — by repairing and protecting your body’s power source.
5-Amino-1MQ
5 amino acids & 5-6 hour half-life
This is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT). As fat cells grow larger, they begin to overproduce NNMT, which is responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. This enzyme increases the metabolism within the white fat cells and reduces the size of fat deposits, while also increasing long-term muscle contractile force by 70%. It also supports metabolic flexibility, allowing the body to switch more efficiently between fat and glucose as energy sources. This makes it a promising therapeutic target for obesity-related metabolic disorders.
MOTS-C
16 amino acids & 20-30 minute half-life
This is a 16-amino acid poly-peptide encoded by mitochondrial DNA. Mitochondria are responsible for 95% of our body’s energy production. MOTS-C increases cellular respiration, reduces HA-1C, promotes metabolic homeostasis, and improves insulin resistance for massive fat loss and hyper-enhanced exercise performance. It also activates AMPK, a key regulator of energy balance, and enhances mitochondrial efficiency. These combined effects make it a powerful tool for optimizing metabolic health and physical performance. Recent studies suggest it may also support healthy aging and longevity through cellular stress resistance.
Tesofensine
8 day half-life
Although not a peptide this is the newest, game-changing form of a peptide–re-uptake inhibitors for weight loss! As a serotonin-noradrenaline-dopamine re-uptake inhibitor, Tesofensine works at the level of the brain by suppressing appetite, satiating reward centers, and increasing resting energy expenditure (your resting metabolic rate). It acts primarily as an appetite suppressant with significant effects on fat oxidation and reduction in fat tissue. Studies have shown a reduction in appetite sensation within 14 days, with those being treated reporting a greater satiety level and less desire to eat.
SLU-PP-332
15 amino acids & 4-6 hour half life
Is a peptide that mimics the metabolic effects of exercise by activating estrogen receptor-related receptors (ERRs), to boost mitochondrial function and enhance fat oxidation. This “exercise-mimicking” peptide offers a range of benefits, including weight loss without lifestyle changes, improved metabolic health, enhanced muscle function, better insulin sensitivity, and protection of vital organs. It’s especially beneficial for individuals with obesity, metabolic syndrome, or physical limitations, as well as aging adults and those at risk for chronic diseases, by improving endurance, muscle performance, and overall energy.
OS-01 (ATX-304) – oral form
Small molecule therapeutic & unknown half-life
OS-01 is a direct pan-AMPK activator, meaning it stimulates all forms of AMPK—the master switch for cellular energy. As we age, AMPK activity declines, slowing metabolism, fat burning, and cellular repair. OS-01 restores this function by preventing deactivation of AMPK and acting as a mild mitochondrial uncoupler, which boosts energy output. This dual action helps improve glucose control, enhance fat metabolism, support cardiovascular performance, reduce inflammation, and protect kidneys and other organs from aging or stress-related damage. In early human trials, OS-01 was well tolerated and demonstrated significant benefits.
